Chelsea captain John Terry has been ruled out of Tuesday's Champions League clash with Paris St Germain after failing to recover from injury, the Premier League club said.
While Pep Guardiola has brought two Premier League titles, smashed records and produced some of the most glorious football the club's fans have ever seen -- European success remains elusive to his team.
Manchester rivals City and United have so far not taken their domestic form into Europe and will be among 15 teams attempting to win their first matches in the Champions League group stage this week.
Second-string Liverpool were thumped 3-0 by Crystal Palace as Ismaila Sarr struck twice for the visitors in the League Cup on Wednesday, booking the London side's spot in the quarter-finals and piling more misery on Arne Slot's struggling side.
A round-up of Tuesday night's matches in the UEFA Champions League.
A record 13 teams will be vying for top honours in the Champions League Twenty20 which will be held across three cities Chennai, Kolkata and Bangalore from September 23 to October 9.
Bosnian champions Sarajevo crushed Marsaxlokk of Malta 6-0 in the first leg of their Champions League qualifier on Wednesday to set up a likely meeting with Genk of Belgium in the second qualifying round.
Atletico Madrid celebrated like they had won the trophy after reaching the Champions League quarter-finals by edging past PSV Eindhoven 8-7 on penalties on Tuesday following 210 goalless minutes in their last-16 tie.
Last-minute starter Adrian Ramos scored a first-half header to give Borussia Dortmund a 1-0 victory over Sporting on Wednesday and earn a spot in the knockout stage of the Champions League with two Group F matches to spare.
She oversaw her first Europa League game in October when Leicester City hosted Zorya Luhansk.
IMAGES from the UEFA Champions League matches played on Tuesday
Manchester United will look to eliminate AC Milan for the first time while Real Madrid seek a maiden victory over Olympique Lyon when the Champions League returns on Tuesday after its winter break.
Cristiano Ronaldo continued from where he left off in the early stages of the UEFA Champions League, adding to his goal tally as Real Madrid beat AS Roma 2-0 in their round of 16, first leg tie on Wednesday.
Sofiane Feghouli's late goal eased the nerves at Valencia's Mestalla as the Spanish club grabbed a 3-1 victory over Monaco in the first leg of their Champions league play-off round tie on Wednesday.
With the away goals rule no longer in place this season, PSV missed a string of chances to force extra time with Eran Zahavi hitting the crossbar from three metres with the goal at his mercy in the 62nd minute.
Manchester United ended their one-year Champions League hiatus in emphatic style when Wayne Rooney struck a hat-trick in a 4-0 destruction of Club Bruges that sent the three-times winners through 7-1 on aggregate on Wednesday.
Photos from the UEFA Champions League round of 16 first leg match played between Benfica and Zenit St Petersburg at the Stadium of Light in Lisbon on Tuesday
In an all-Spanish clash, former winners Barcelona were drawn against Atletico Madrid in the Champions League draw, while Real Madrid will take on Borussia Dortmund. Paris Saint-Germain were handed a tough draw against Chelsea.
PSV Eindhoven will miss striker Luuk de Jong when they entertain Atletico Madrid in the first leg of the Champions League last 16 on Wednesday.
Arsenal eased into the group stages of the Champions League on Wednesday by outclassing Celtic 3-1 to enter Thursday's draw where they will be joined by Fiorentina, VfB Stuttgart, Olympiakos and APOEL Nicosia.
Wednesday's Liverpool - Chelsea match is the most eagerly anticipated Champions League quarter-final first leg this week despite the pair having met in the competition in each of the last four seasons. Holders Manchester United host Porto on Tuesday, five years after the Portuguese club knocked out Alex Ferguson's side on their way to winning the 2004 Champions League.
Lionel Messi scored twice in the second half to help Barcelona to a 2-0 win over Arsenal in their UEFA Champions League round of 16, first leg match at the Emirates Stadium in London on Tuesday.
Celtic, who won Europe's premier club competition in 1967, set up a clash with Romanians Cluj in the next stage after a 2-0 win at Nomme Kalju completed a 7-0 aggregate rout of the Estonian champions.
Luis Suarez said Barcelona have not given up on the Champions League despite a "difficult and painful" 4-0 drubbing by Paris St Germain in their last 16 tie this week.
Borussia Moenchengladbach's hopes of qualifying for the Champions League suffered a blow as they were beaten 2-0 at bottom club Hanover 96 on Friday.
Juventus scored twice in a minute as they came from behind to clinch a dramatic 3-2 win over Olympiakos after Andrea Pirlo had celebrated his 100th Champions League appearance by scoring from a characteristically effortless free kick on Tuesday.
England captain Harry Brook expresses confidence in his team's ability to defeat India in the T20 World Cup semifinal, highlighting their resilience and the potential of their top-order batters.
Erling Haaland is the tenth player to reach the landmark of 50 goals in the UEFA Champions League and fastest to do so, beating the 62-match record of Ruud van Nistelrooy.
Manchester United pull off one of the greatest comebacks in Champions League history.
Jose Mourinho's job could be on the line when Chelsea host Porto in the Champions League on Wednesday and Alex Ferguson has urged the Londoners not to jettison their manager even if the result goes against them.
Defending champions Bayern Munich survived a shaky second half and missed a late penalty against Arsenal on Tuesday to reach the Champions League quarter-finals.
England and Germany will be left without any teams in the Champions League quarter-finals unless Chelsea and Bayern Munich can overturn first-leg deficits in this week's ties.
"Tomorrow we don't play six points against zero. We play at 7.45, at 0-0 with 90 minutes to go," he said.
Facts and figures ahead of Saturday's Champions League final between holders Real Madrid and Liverpool in Kiev:
Paris St Germain played out their first goalless draw of the season at Athletic Bilbao on Wednesday but stayed in the driving seat for direct qualification for the Champions League last-16 after a string of fine saves by home goalkeeper Unai Simon denied the defending champions.
Barcelona's star striker Lionel Messi has backed Atletico Madrid to seal this year's Champions League title, saying his team don't want to see Real Madrid claim the trophy.
Reigning classical World champion D Gukesh, Arjun Erigaisi and world No.1 Magnus Carlsen were among the leaders after the first five rounds on the opening day of the FIDE World Rapid Championships in Doha on Thursday.
Video footage showed several Real players dancing and making gestures towards the Atletico supporters, who responded by throwing objects from the stands.
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